1,5-Isoquinolinediol
CAS No. : 5154-02-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $80 | In-stock |
| 250mg | $120 | In-stock |
| 1g | $310 | In-stock |
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| Cat. No. : | HY-W015422 |
| M.Wt: | 161.16 |
| Formula: | C9H7NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 37.04 mg/mL (ultrasonic) |
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina[1][2].
In Vitro: 1,5-isoquinolinediol leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene[1].
1,5-Isoquinolinediol is a potent PARP antagonist and decreases cleaved PARP in diabetic retina.
1,5-Isoquinolinediol (500 μM H2O2; 24 hours) attenuates H2O2-induced upregulation of cleaved PARP-1 expression in retinal Muller cells. 1,5-Isoquinolinediol attenuates diabetes-induced upregulation of retinal nitrated protein expression. 1,5-Isoquinolinediol attenuates diabetes-induced activation of NADPH oxidase in the retina[2].
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