alpha-Bisabolol
CAS No. : 515-69-5
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| Cat. No. : | HY-121222 |
| M.Wt: | 222.37 |
| Formula: | C15H26O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394)-induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities[1][2].
In Vitro: alpha-Bisabolol (3.2-120 µM; 24 h) exerts antiproliferative effects on A549 cells[1].
alpha-Bisabolol (7.5-30 µM; 24 h) caused apoptosis in A549 cells in a concentration-dependent manner[1].
alpha-Bisabolol (7.5-30 µM; 24 h) induces G2/M cell cycle arrest of A549 cells[1].
alpha-Bisabolol (15 µM; 24 h) reduces the motility and migration of the of A549 cells in a dose-dependent manner[1].
alpha-Bisabolol (15 µM; 24 h) exhibits a dose-dependent downregulation of p-PI3K and p-AKT proteins[1].
In Vivo: reduces the Cisplatin (HY-17394)-induced renal DNA damage, and markedly lessened the acute tubular necrosis observed in kidney histology[2].
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