β-Elemene
CAS No. : 515-13-9
(Synonyms: (-)-β-Elemene; Levo-β-elemene)
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $140 | In-stock |
| 100mg | $160 | In-stock |
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| Cat. No. : | HY-107324 |
| M.Wt: | 204.36 |
| Formula: | C15H24 |
| Purity: | >98 % |
| Solubility: | Ethanol : 50 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma aromatica with an antitumor activity. β-Elemene can induce cell apoptosis. In Vitro: β-Elemene (0-200 µg/ml; 24 hours) shows IC50 values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively[1]. β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml, induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase [1]. β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells [1]. β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway[1].
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