COG 133
CAS No. : 514200-66-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $250 | In-stock |
| 10mg | $390 | In-stock |
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| Cat. No. : | HY-P1050 |
| M.Wt: | 2169.71 |
| Formula: | C97H181N37O19 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2]. IC50 & Target: IC50: 445 nM (nAChR)[2] In Vivo: COG 133 (1 mg/kg; intratracheal administration; every other day; for 4 weeks) treatment impairs the resolution of pulmonary fibrosis in mice[3].
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