Fludrocortisone acetate
CAS No. : 514-36-3
(Synonyms: 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate)
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| 500mg | $60 | In-stock |
| 1g | $87 | In-stock |
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| Cat. No. : | HY-B1203A |
| M.Wt: | 422.49 |
| Formula: | C23H31FO6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Fludrocortisone acetate (9α-Fludrocortisone acetate) is an orally active synthetic mineralocorticoid. Fludrocortisone acetate can effectively control sodium retention. Fludrocortisone acetate is used in studies of cardiac injury, adrenal insufficiency and orthostatic hypotension[1][2][3].
In Vitro:Fludrocortisone acetate is more effective than glucocorticoid Triamcinolone acetonide (HY-B0636) in restoring quiescent morphology and reducing membrane permeability in Phorbol-12-myristate-acetate (PMA)-stimulated choroidal endothelial cells (CECs)[1].
In Vivo:Fludrocortisone acetate (250 μg/kg/day, p.o.) combined with 1% saline (NaCl) solution induces cardiac injury in rats, with reducing antioxidant enzyme (GSH, SOD and CAT) activities[2].
Fludrocortisone acetate (0.05 mg/kg, p.o., twice daily, 4 consecutive days) results in a significant decrease in the UACR in healthy cats[3].
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