Budesonide
CAS No. : 51333-22-3
| Size | Price | Stock |
|---|---|---|
| 100mg | $60 | In-stock |
| 200mg | $103 | In-stock |
| 500mg | $234 | In-stock |
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| Cat. No. : | HY-13580 |
| M.Wt: | 430.53 |
| Formula: | C25H34O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 215 mg/mL (ultrasonic;warming) |
Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide decreases the size of lung tumors, reverses DNA hypomethylation and modulates mRNA expression of genes. Budesonide is an anti-inflammatory agent used for asthma[1][2][3].
In Vitro: Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1].
Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2].
In Vivo: Budesonide (2.0 mg/kg; orally via their diet; at 2, 7 and 21 days prior to killing) decreases the size of lung tumors[3].
Budesonide (0.5 mg/kg; intranasal administration 1 h before LPS injection (5 mg/kg)) pretreatment dramatically attenuates pathological injury and reduces pathological scores in mice with ALI in adult male C57BL/6 mice[2].
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