Sparfosic acid
CAS No. : 51321-79-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $228 | In-stock |
| 5mg | $575 | In-stock |
| 10mg | $820 | In-stock |
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| Cat. No. : | HY-112732 |
| M.Wt: | 255.12 |
| Formula: | C6H10NO8P |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic) |
Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3].
In Vitro: Sparfosic acid (N-(Phosphonacetyl)-L-aspartate, PALA) causes apoptosis in the resistant Br1 cells[1].
Sparfosic acid (300 µM) shows progressive accumulation of cells in S phase and activation of an apoptotic pathway leading to cell death[1].
In Vivo: Sparfosic acid (490 mg/kg; i.p.; on days 1, 5, and 9; mice bearing B16 melanoma) shows the life-span is increased survives 77 to 86% longer than controls. Lewis lung carcinoma is highly sensitive to Sparfosic acid. Treatment on days 1, 5, and 9 following s.c. implantation of Lewis lung carcinoma is curative to 50% of the mice[4].
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