Buthiobate
CAS No. : 51308-54-4
(Synonyms: S-1358)
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| Cat. No. : | HY-118558 |
| M.Wt: | 372.59 |
| Formula: | C21H28N2S2 |
| Purity: | >98 % |
| Solubility: |
Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops[1][2].
In Vitro:Buthiobate (0.4-10 μM; 30 min) potently inhibits lanosterol 14α-demethylase activity in rat liver microsomes with an IC50 of 0.4 μM, and achieves near-complete inhibition at 10 μM[1].
Buthiobate (10-6-10-4 M; 3 h) potently inhibits C-14 demethylation in ergosterol biosynthesis in cell-free homogenates of Saccharomyces cerevisiae, with the strongest effect observed at 10-4 M, resulting in accumulation of lanosterol and reduced formation of downstream sterols[2].
Buthiobate (various concentrations; 36 μM) binds to three distinct low-spin cytochrome P-450 species in rat liver microsomes with KD values ranging from 0.38 to 13.2 μM[1].
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