FAPy-adenine
CAS No. : 5122-36-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $64 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $420 | In-stock |
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| Cat. No. : | HY-113303 |
| M.Wt: | 153.15 |
| Formula: | C5H7N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 17.86 mg/mL (ultrasonic) |
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3]. In Vitro: In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine[1]. In Vivo: The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1].
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