Raffinose
CAS No. : 512-69-6
(Synonyms: Melitose)
| Size | Price | Stock |
|---|---|---|
| 50mg | $30 | In-stock |
| 100mg | $50 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N7088 |
| M.Wt: | 504.44 |
| Formula: | C18H32O16 |
| Purity: | >98 % |
| Solubility: | H2O : 250 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Raffinose (Melitose) regulates intestinal flora, inhibits TLR4-MyD88-NF-κB signaling pathway, and activates Nrf2 signaling pathway. Raffinose exhibits anti-inflammatory, antioxidant, and immunomodulatory activities. Raffinose is orally active[1][2][3].
IC50 & Target:IC50: short-chain oligosaccharide[1]
In Vitro:Raffinose (0-200 mM, 48 h) enhances the autophagic flux of HaCaT cells, reduces the LDH release, and protects HaCaT cell from UVB-induced damage[2].
Raffinose (0-10 mM, 24 h) regulates the expression of lipid metabolism-related proteins, alleviates lipid accumulation in Oleic acid (HY-N1446)-induced AML12 cell[3].
Raffinose (0-10 mM, 24 h) activates the Nrf2/Keap1 signaling pathway, inhibits Oleic acid (HY-N1446)-induced pyroptosis and NLRP3 inflammasome formation in AML12 cell[3].
In Vivo:Raffinose (100-400 mg/kg, po, once daily for 21 days) improves oxidative stress, regulates immune responses, improves intestinal flora imbalance, and ameliorates DSS (HY-116282C)-induced colitis symptoms in mouse models[1].
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