Echinomycin
CAS No. : 512-64-1
(Synonyms: Quinomycin A; NSC-13502)
| Size | Price | Stock |
|---|---|---|
| 1mg | $360 | In-stock |
| 5mg | $1400 | In-stock |
| 10mg | $2520 | In-stock |
| 25mg | $5500 | In-stock |
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| Cat. No. : | HY-106101 |
| M.Wt: | 1101.26 |
| Formula: | C51H64N12O12S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 5.3 mg/mL (ultrasonic) |
Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. In Vitro: Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1]. In Vivo: Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway[2].
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