Yamogenin
CAS No. : 512-06-1
(Synonyms: Neodiosgenin)
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| 10mg | $210 | In-stock |
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| Cat. No. : | HY-N2078 |
| M.Wt: | 414.62 |
| Formula: | C27H42O3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 8.33 mg/mL (ultrasonic) |
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes. Yamogenin is a steroidal saponin that can be obtained from plant species with in vitro cytotoxicity, antioxidant, and antimicrobial properties. Yamogenin induces cell death via the extrinsic and intrinsic way of apoptosis. Yamogenin inhibits protein denaturation with an IC50 of 1421.92 μg/mL. Yamogenin can be studied in research on gastric cancer[1][2].
IC50 & Target:IC50: TG accumulation; liver X receptor (LXR)[1]
In Vitro:Yamogenin (5-60 µg/mL, 24 h) decreases the viability of AGS cells with an IC50 of 18.5 µg/mL[2].
Yamogenin (10-60 µg/mL, 24 h) increases the amount of apoptotic and dead AGS cells[2].
Yamogenin (10-60 µg/mL, 48 h) induces cell cycle arrest in subG1 phase in AGS cells[2].
Yamogenin (30-100 µg/mL,5-24 h) triggers activation of caspase-8 and -9 in AGS cells[2].
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