Diosgenin
CAS No. : 512-04-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $55 | In-stock |
| 500mg | $80 | In-stock |
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| Cat. No. : | HY-N0177 |
| M.Wt: | 414.62 |
| Formula: | C27H42O3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : < 1 mg/mL;Ethanol : 3.33 mg/mL (ultrasonic) |
Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway[1]. Diosgenin is an exogenous activator of Pdia3/ERp57[2]. Diosgenin inhibits aortic atherosclerosis progression by suppressing macrophage miR-19b expression[5].
In Vitro:In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[3]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[1].
Diosgenin (10 μM; 24 h) significantly decreases the levels of miR-19b in foam cells[5].
In Vivo:Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[4].
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