(R)-(-)-Ibuprofen
CAS No. : 51146-57-7
(Synonyms: (R)-Ibuprofen)
| Size | Price | Stock |
|---|---|---|
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| 250mg | $55 | In-stock |
| 1g | $100 | In-stock |
| 5g | $355 | In-stock |
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| Cat. No. : | HY-78131B |
| M.Wt: | 206.28 |
| Formula: | C13H18O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. IC50 & Target: NF-κB[2] In Vitro: (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids[1]. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF[2].
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