Pifithrin-β (hydrobromide)
CAS No. : 511296-88-1
(Synonyms: PFT β (hydrobromide); Cyclic Pifithrin-α (hydrobromide))
| Size | Price | Stock |
|---|---|---|
| 5mg | $73 | In-stock |
| 10mg | $111 | In-stock |
| 25mg | $222 | In-stock |
| 50mg | $333 | In-stock |
| 100mg | $630 | In-stock |
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| Cat. No. : | HY-16702A |
| M.Wt: | 349.29 |
| Formula: | C16H17BrN2S |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM. IC50 & Target:IC50: 23 μM (p53)[1] In Vitro: Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].
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