8-pCPT-2′-O-Me-cAMP
CAS No. : 510774-50-2
(Synonyms: 8-CPT-2'-O-Me-cAMP)
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| Cat. No. : | HY-116312 |
| M.Wt: | 485.84 |
| Formula: | C17H17ClN5O6PS |
| Purity: | >98 % |
| Solubility: |
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP), an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration[1][2][3]. IC50 & Target:Rap1[1] In Vitro:8-CPT-2'-O-Me-cAMP (250 µM; 1 h) induces Rap1 activation and enhances recruitment of junctional proteins and cortical F-actin in retinal pigment epithelium cells[1]. In Vivo:8-CPT-2'-O-Me-cAMP (2.05 µM; 1 µL; intravitreal injection) inhibits development of choroidal neovascular lesions in a laser-injury model[1].
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