Wogonoside


CAS No. : 51059-44-0

51059-44-0
Price and Availability of CAS No. : 51059-44-0
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1mg $26 In-stock
5mg $55 In-stock
10mg $88 In-stock
20mg $154 In-stock
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Cat. No. : HY-N0399
M.Wt: 460.39
Formula: C22H20O11
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 51059-44-0 :

Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2]. In Vitro:Wogonoside (0-50 μM, 24 h) inhibits the production of inflammatory mediators (NO, PGE2), and pro-inflammatory cytokines (TNF-α and IL-6) in LPS-induced RAW264.7 cells[1].
Wogonoside (0-400 μM, 24 h) inhibits growth of MDA-MB-231 and MCF-7[2].
Wogonoside (100 μM, 9-24 h) induces autophagy in MDA-MB-231 cells[2].
Wogonoside (50-150 μM, 48-96 h) inhibits proliferation, induces G1 phase arrest, and differentiation in U937 and HL-60 cells[5].
In Vivo:Wogonoside (80 mg/kg, oral gavage, once every other day) inhibits tumor growth and metastasis in MDA-MB-231 orthotopic model[3].
Wogonoside (40 or 80 mg/kg, i.p., every three days) inhibits tumor growth and reduces Bcl-2/Bax ratio in A549 cell xenograft mice[4].
Wogonoside (80 mg/kg, i.P., every other day for 14 days) also inhibits tumor growth in U937 xenograft model[5].

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