Flurbiprofen
CAS No. : 5104-49-4
(Synonyms: dl-Flurbiprofen)
| Size | Price | Stock |
|---|---|---|
| 1g | $18 | In-stock |
| 5g | $43 | In-stock |
| 10g | $52 | In-stock |
| 25g | $124 | In-stock |
| 100g | $204 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-10582 |
| M.Wt: | 244.26 |
| Formula: | C15H13FO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Flurbiprofen (dl-Flurbiprofen) is a potent, orally active nonsteroidal anti-inflammatory agent (NSAIA/NSAID), with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor that can be used for the research of colorectal cancer[1][2][3].
IC50 & Target:COX[1]
In Vitro: Flurbiprofen (2-20 nM; 12-48 hours) significantly decreases SW620 cells proliferation in a concentration- and time-dependent manner[1].
Flurbiprofen (10 nM; 24 hours) decreases COX-2 expression[1].
Flurbiprofen (10 nM; 24 hours) inhibits the expression of inflammatory factors by inhibiting COX-2[1].
Flurbiprofen (10 nM; 24 hours) promotes the apoptosis of colorectal cancer cells by inhibiting COX-2[1].
In Vivo: Flurbiprofen (0.3-4.8 mg/kg; p.o.; 4-5 dosages) has acute anti-inflammatory in adrenalectomized rats[2].
Flurbiprofen (10 mg/kg; i.p.; daily; for 6 days) attenuates high-fat diet-induced obesity in mice[3].
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