| Size | Price | Stock |
|---|---|---|
| 5mg | $268 | In-stock |
| 10mg | $430 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-N2252 |
| M.Wt: | 326.39 |
| Formula: | C20H22O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1].
In Vitro: Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].
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