Licarin A


CAS No. : 51020-86-1

(Synonyms: (+)-Licarin A)

51020-86-1
Price and Availability of CAS No. : 51020-86-1
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10mg $430 In-stock
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Cat. No. : HY-N2252
M.Wt: 326.39
Formula: C20H22O4
Purity: >98 %
Solubility: DMSO : ≥ 50 mg/mL;H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 51020-86-1 :

Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression[1]. In Vitro: Licarin A is found in plants such as Aristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects[1].
Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels[1].

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