Urethane
CAS No. : 51-79-6
(Synonyms: Ethyl carbamate; Carbamic acid ethyl ester; Ethylurethane)
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| 1000g | $75 | In-stock |
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| Cat. No. : | HY-B1207 |
| M.Wt: | 89.09 |
| Formula: | C3H7NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Urethane (Ethyl carbamate), the ethyl ester of carbamic acid, is a byproduct of fermentation found in various food products. Urethane has the ability to suppress bacterial, protozoal, sea urchin egg, and plant tissue growth in vitro[1].
In Vitro:Urethane is a good clastogen in mammalian somatic cells in vivo, but it shows variable results with cells in vitro. Urethane efficiently induces sister chromatid exchanges in a variety of cells[2].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Urethane can be used in animal modeling to create lung tumor models. Approximately 90% of Urethane is hydrolyzed to ethanol, ammonia, and carbon dioxide by hepatic microsomal esterases (carboxylesterases), while only 5% of Urethane is excreted unchanged. A very small amount of Urethane is converted by the cytochrome P450 enzyme CYP2E1 to ethylene urea, leading to the formation of an epoxide (ethylene urea epoxide). This epoxide covalently binds to DNA and may cause base misincorporation during DNA replication, thereby inducing point mutations[1][2].
Administration: 1 g/kg (in 100 μL saline)• i.p.• once per week for 16 weeks or every other day for a week[1]
(2) After mice were sacrificed, lungs were harvested, and the number of tumors and their diameter on the lung surface were measured. Serum was also collected after centrifugation[1].
Tumor changes: Urethane administration significantly increased the average number, size and diameter of tumors in PRDX4 Tg mice. Tumor apoptosis was suppressed and tumor proliferation was enhanced in Tg mice[1].
Histology analysis: Urethane administration increased microvascular permeability and macrophage infiltration in lung tumor of PRDX4 Tg mice[1].
Metabolic change: Urethane administration inhibited oxidative stress and decreased gene expressions of antioxidant enzymes (SOD1 and SOD2) in Tg mice[1].
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