Dopamine
CAS No. : 51-61-6
(Synonyms: ASL279 (free base))
| Size | Price | Stock |
|---|---|---|
| 10mg | $77 | In-stock |
| 25mg | $125 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $240 | In-stock |
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| Cat. No. : | HY-B0451 |
| M.Wt: | 153.18 |
| Formula: | C8H11NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1]. In Vitro: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µM; 24hours)[2]. In Vivo: Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF[2].
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