Propylthiouracil


CAS No. : 51-52-5

(Synonyms: 6-n-Propylthiouracil; 6-Propyl-2-thiouracil; PTU)

51-52-5
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Cat. No. : HY-B0346
M.Wt: 170.23
Formula: C7H10N2OS
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL;H2O : < 0.1 mg/mL (ultrasonic)
Introduction of 51-52-5 :

Propylthiouracil (6-n-Propylthiouracil), a thioamide antithyroid agent, is an orally active thyroperoxidase and type-1 deiodinase (DIO1) inhibitor. Propylthiouracil can be used for the Graves disease and hyperthyroidism research[1]. In Vitro:Propylthiouracil (5.5-330 μg/mL; 24 h) induces growth retardation and cytotoxicity in a dose-dependent manner in U-937 cells[2]. In Vivo:Propylthiouracil induces hypothyroidism in adult C57BL/6J and wild-derived WSB/EiJ male mice by given an iodine-deficient diet supplemented with 0.15% Propylthiouracil[1].

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