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Norepinephrine (tartrate)


CAS No. : 51-40-1

(Synonyms: Levarterenol (tartrate); L-Noradrenaline (tartrate))

51-40-1
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Cat. No. : HY-13715C
M.Wt: 319.26
Formula: C12H17NO9
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 51-40-1 :

Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is a potent adrenergic receptor (AR) agonist. Norepinephrine tartrate activates α1, α2, β1 receptors[1][2][3][4]. IC50 & Target:EC50: 5.37 μM (β1-selective adrenergic receptor)[1]. In Vitro:Norepinephrine (Levarterenol; L-Noradrenaline) tartrate is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) tartrate also has direct activity at the β2-adrenoceptor in higher concentrations[2].
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production. CREB phosphorylation at Ser133 is increased after Norepinephrine (NE) treatment and significantly attenuated with CGP co-treatment in mouse iWA[3]. In Vivo:

Norepinephrine tartrate can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6]
Background
Norepinephrine tartrate is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine tartrate in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine tartrate activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats • adult (6 months old) • male Administration: Continuously injected via an osmotic minipump • 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators
Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): /
Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)

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