Nialamide
CAS No. : 51-12-7
| Size | Price | Stock |
|---|---|---|
| 25mg | $44 | In-stock |
| 50mg | $66 | In-stock |
| 100mg | $100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-B1199 |
| M.Wt: | 298.34 |
| Formula: | C16H18N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Nialamide is a non-selective monoamine oxidase (MAO) inhibitor. Nialamide inhibits MAO and regulates ROS production. Nialamide induces hyperkinesis in animals, enhances the anticonvulsant effect of Diphenylhydantoin in mice, increases rectal temperature, and enhances the pressor effect of Norepinephrine. Nialamide can be used in the research of depression, inflammatory diseases, neurodegenerative diseases, and hypertension[1][2][3][4][5][6].
In Vitro:Nialamide (10 μM) decreases ROS levels in NMDA (HY-17551)- and Kainic acid (HY-N2309)- stimulated rat cerebellar granule cells[1].
In Vivo:Nialamide (100 mg/kg; s.c.) enhances hypermotility in female NMRI mice[3].
Nialamide (1-10 mg/kg; i.v.) potentiates Noradrenaline's pressor effect in Reserpine (HY-N0480)-pretreated pithed cats[4].
Nialamide (100 mg/kg; i.p.) enhances the anticonvulsant effect of Diphenylhydantoin in mice[5].
Nialamide (200 mg/kg; i.p.) induces increased motor activity, rectal temperature, and elevated brain 5-HT, NA, and dopamine levels in mice[6].
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