Pronethalol (hydrochloride)
CAS No. : 51-02-5
(Synonyms: (±)-Pronethalo (hydrochloride))
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| Cat. No. : | HY-B1238A |
| M.Wt: | 265.78 |
| Formula: | C15H20ClNO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
In Vitro: Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].
In Vivo: Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].
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