Sodium 2-hydroxybutanoate
CAS No. : 5094-24-6
(Synonyms: 2-Hydroxybutyric acid (sodium))
| Size | Price | Stock |
|---|---|---|
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| 1g | $40 | In-stock |
| 5g | $140 | In-stock |
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| Cat. No. : | HY-W012790 |
| M.Wt: | 126.09 |
| Formula: | C4H7NaO3 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite[1]. Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia[2][4]. Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury[3].
In Vitro:Sodium 2-hydroxybutanoate is synthesized as coproduct of insulin resistance, causes insulin signaling impairment and mitochondrial overload[2].
Sodium 2-hydroxybutanoate (0-40 mM) enhances the cell viabilities and decreases the AP-induced cytotoxicities of BRL3A, AML12 and mice primary hepatocytes[3].
In Vivo:Sodium 2-hydroxybutanoate (250 mg/kg/day, i.p. for 3 days) prevents C57 mice from the AP-induced liver injury, normalizes the expressions of genes involved in inflammation response, oxidative stress, cell proliferation and DNA damage[3].
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