Mizoribine
CAS No. : 50924-49-7
(Synonyms: NSC 289637; HE 69)
| Size | Price | Stock |
|---|---|---|
| 100mg | $48 | In-stock |
| 250mg | $98 | In-stock |
| 1g | $346 | In-stock |
| 5g | $1209 | In-stock |
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| Cat. No. : | HY-17470 |
| M.Wt: | 259.22 |
| Formula: | C9H13N3O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant[1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively[2].
IC50 & Target:HCV[1]; IMPDH; SARS-CoV[2]
In Vitro: Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects[1].
Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome [2].
In Vivo: Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg[3].
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