IRAK4-IN-5
CAS No. : 509093-72-5
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| Cat. No. : | HY-122707 |
| M.Wt: | 478.51 |
| Formula: | C27H25F3N4O |
| Purity: | >98 % |
| Solubility: |
IRAK4-IN-5 is an interleukin-1 receptor-associated kinase 4 (IRAK-4) inhibitor with a Ki value of 2.8 nM. IRAK4-IN-5 interacts with non-conserved residues of IRAK-4, thereby conferring selectivity over related kinases. IRAK4-IN-5 can be used in the research of inflammatory lesions (atherosclerosis, arthritis)[1].
In Vitro:IRAK4-IN-5 (compound 16) inhibits IL-1-induced NF-κB activation in primary human monocytes with an IC50 of 0.3 μM[1].
IRAK4-IN-5 potently binds purified IRAK-4 with a Ki of 2.8 nM, and exhibits 217-fold selectivity over IRAK-1 and 892-fold selectivity over TAK1[1].
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- Cat. No.:
- HY-122707
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