BMS-587101
CAS No. : 509083-77-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1650 | In-stock |
| 50mg | $2600 | In-stock |
| 100mg | $4200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120628 |
| M.Wt: | 555.43 |
| Formula: | C26H20Cl2N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 260 mg/mL (ultrasonic) |
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research[1][2].
In Vitro: BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production[1][2].
In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC50 of 150 nM[1].
In Vivo: In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation[1].
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