Mitraphylline
CAS No. : 509-80-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $280 | In-stock |
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| Cat. No. : | HY-N6946 |
| M.Wt: | 368.43 |
| Formula: | C21H24N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.76 mg/mL (ultrasonic) |
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].
In Vitro:Mitraphylline (25 μM) significantly reduces the NO production in human LPS-activated neutrophils[1].
Mitraphylline (25 μM, 6 h) significantly downregulates the pro-inflammatory cytokines in LPS-treated neutrophils[1].
Mitraphylline (0-40 μM, 48 h) inhibits cell viability dose-dependently in both GAMG (IC50 = 20.05 μM) and SKN-BE cells[3].
In Vivo:Mitraphylline (30 mg/kg/day, p.o., 3 d) impairs the liberation of TNF-α by 50% and inhibits IL-1α/β in mice[2].
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