Songorine

Songorine is a BBB-permeable diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)^[1][2][3]. IC50 & Target:IC50: GABAA receptor^[1] In Vivo:Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax^[1].
Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD₅₀ and ED₅₀ values of 142 mg and 7.3mg, respectively^[2].