Ibudilast
CAS No. : 50847-11-5
(Synonyms: KC-404; AV-411; MN-166)
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $46 | In-stock |
| 50mg | $65 | In-stock |
| 100mg | $101 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-B0763 |
| M.Wt: | 230.31 |
| Formula: | C14H18N2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 140 mg/mL;H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[1].
IC50 & Target: phosphodiesterase[1]
In Vitro: Ibudilast (1~100 μM; 24 hours; microglia) suppresses both IL-1β and IL-6 production at 100 µM, and significantly suppresses TNF-α production at 10 and 100 µM[1].
Ibudilast (1~100 μM; 48 hours; neuronal cells) significantly increases the neuronal survival rate. Ibudilast (1~100 μM; 48 hours; microglia) inhibits the production of superoxide and NO[1].
Ibudilast upregulates the production of IL-10 in a dose-dependent manner. Ibudilast increases NGF mRNA and protein levels and GDNF and NT-4 mRNA expression. Ibudilast decreases the apoptotic changes observed in the neuronal cells in a dose-dependent manner[1].
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