Convallatoxin


CAS No. : 508-75-8

508-75-8
Price and Availability of CAS No. : 508-75-8
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1mg $75 In-stock
5mg $180 In-stock
10mg $280 In-stock
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Cat. No. : HY-N2453
M.Wt: 550.64
Formula: C29H42O10
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 508-75-8 :

Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties[1][2][3]. In Vitro: Convallatoxin induces HaCaT cell necroptosis[4]. In Vivo: Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4].

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