Polyphyllin I
CAS No. : 50773-41-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0047 |
| M.Wt: | 855.02 |
| Formula: | C44H70O16 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic) |
Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].
IC50 & Target:JNK signaling[2]
PDK1/Akt/mTOR signaling[3]
In Vitro:Polyphyllin I (0.625-10 mg/mL; 24-72 h) inhibits the proliferation of three non-small cell lung cancer (NSCLC) cell lines, with the IC50s of 1.24, 2.40, and 2.33 μg/ml for A549, H460, and SK-MES-1 cells, respectively[1].
Polyphyllin I (2.5 mg/mL; 6-24 h) induces apoptosis of A549 cells[1].
Polyphyllin I (0.25-2 μM; 24 h) increase in LC3-II expression and decrease in P62 expression in HGC-27 cells[3].
In Vivo:Polyphyllin I (1.5 mg/kg; i.p. twice daily from day 2 to day 11) significantly inhibit the tumor growth of A549 cells in the nude mice[1].
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