Vecuronium (bromide)
CAS No. : 50700-72-6
(Synonyms: ORG NC 45)
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| Cat. No. : | HY-B0118A |
| M.Wt: | 637.73 |
| Formula: | C34H57BrN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 46 mg/mL;H2O : ≥ 100 mg/mL |
Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia[1][2]. In Vitro: Vecuronium bromide (0-100 μM, 15 min) inhibits [3H] norepinephrine (NE) uptake to 65% at 100 μM in adrenal medullary cells[1]. Vecuronium bromide (0-15 μM,72 hours) inhibits cancer cell proliferation and migration in a concentration-dependent manner[2]. Vecuronium bromide (0-15 μM,72 hours) can significantly reduce cell viability by combining with cisplatin[2]. In Vivo: Vecuronium bromide (Intravenous injection, 0-5 μM, every 30 min, 2 hours) attenuates the response of carotid sinus nerve activity (CSNA) to hypoxia in a dose-dependent manner and inhibits the neural response of the carotid body to acetylcholine (ACh) in Wister rats[3].
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