NAPQI
CAS No. : 50700-49-7
(Synonyms: N-Acetyl-4-benzoquinone Imine)
| Size | Price | Stock |
|---|---|---|
| 1mg | $290 | In-stock |
| 5mg | $850 | In-stock |
| 10mg | $1250 | In-stock |
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| Cat. No. : | HY-W017464 |
| M.Wt: | 149.15 |
| Formula: | C8H7NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver[1][2].
In Vitro:NAPQI (25-400 μM, 30 min) inhibits the synthesis of glutathione synthase (GS)[3].
NAPQI (0.15 mg/mL, 24-48 h) is toxic to auditory cell HEI-OC1 through oxidation and endoplasmic reticulum stress-dependent pathways[4].
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