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Arachidonic acid


CAS No. : 506-32-1

(Synonyms: Immunocytophyt)

506-32-1
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Cat. No. : HY-109590
M.Wt: 304.47
Formula: C20H32O2
Purity: >98 %
Solubility: Ethanol : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic)
Introduction of 506-32-1 :

Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 fatty acid and a major constituent of biomembranes. Arachidonic acid also acts as the substrate for various lipid mediators, such as prostaglandins (PGs). Arachidonic acid improves cognitive response and cardiovascular function[1]. In Vitro:Arachidonic acid (0-100 µM, 24-72 h) decreases the viability of HL-60 cells in time- and dose-dependent manner[3].
Arachidonic acid (0-100 µM, 6-24 h) reduces the G0-G1, S and G2-M DNA with increasing concentration and exposure time in HL-60 cells[3].
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Arachidonic acid can be used to induce paw edema models[2].

Induction of Paw Edema Model[2]
Background
Principle: Injecting arachidonic acid into the hind paws of rats can induce rapid and sustained inflammatory responses.
Specific Modeling Methods
Rat: Lewis • male •
Administration: 0.5% • s.c. • single dose
Note
A single subcutaneous injection of 0.10 mL of arachidonic acid (dissolved in 0.2 M carbonate buffer with a pH value of 8.43-8.56) was administered into the right hind paw of male Lewis rats weighing 144-241 grams.
Modeling Indicators
Appearance Monitoring: Significant edema became apparent within 5 minutes, and the reaction reached its peak at 1 hour after injection.
Opposite Product(s): phenidone (HY-W010144); SK&F86002 (HY-12511)

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