Thalidomide-4-OH
CAS No. : 5054-59-1
(Synonyms: Cereblon ligand 2; E3 ligase Ligand 2)
| Size | Price | Stock |
|---|---|---|
| 1g | $10 | In-stock |
| 5g | $29 | In-stock |
| 10g | $56 | In-stock |
| 25g | $139 | In-stock |
| 100g | $553 | In-stock |
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| 500 g | Get quote | |
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| Cat. No. : | HY-103596 |
| M.Wt: | 274.23 |
| Formula: | C13H10N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 36.5 mg/mL |
Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1]. In Vitro: Thalidomide may exert anti-angiogenic effect in isolated blood vessels and endothelial cells. Thalidomide-OH is a putative hydroxylated thalidomide metabolite. Thalidomide-OH has weak anti-angiogenic activity (14% mean inhibition of blood vessel density at 100 mg). Thalidomide-OH does not have any anti-proliferative effect against the breast or neuroblastoma cells, but do possess appreciable anti-proliferative activity against the endothelial cells[1].
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