Iberverin


CAS No. : 505-79-3

(Synonyms: 3-Methylthiopropyl isothiocyanate)

505-79-3
Price and Availability of CAS No. : 505-79-3
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500mg $50 In-stock
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Cat. No. : HY-121204
M.Wt: 147.26
Formula: C5H9NS2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 505-79-3 :

Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species[1]. In Vitro: Iberverin (0-200 μM, 48 h) inhibits the viability and proliferation of HCC cells, with IC50s less than 25 μM for Huh7, Huh7.5.1, and SNU739[1].
Iberverin (10 μM, 24-72 h) inhibits migration and invasion in Huh7, Huh7.5.1 and SNU739 cells[1].
Iberverin (40 μM, 12 h) induces mitochondrial-related apoptosis, induces DNA damage and causes G2/M cell cycle arrest in Huh7, Huh7.5.1 and SNU739 cells[1].
In Vivo: Iberverin (20 mg/kg, i.p., every 3 days for five cycles) inhibits the growth of HCC xenograft tumor in mice[1].

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