Hexadecanedioic acid
CAS No. : 505-54-4
(Synonyms: Thapsic acid)
| Size | Price | Stock |
|---|---|---|
| 1g | $12 | In-stock |
| 5g | $15 | In-stock |
| 10g | $18 | In-stock |
| 25g | $22 | In-stock |
| 100g | $36 | In-stock |
| 500g | $178 | In-stock |
| 1000g | $356 | In-stock |
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| Cat. No. : | HY-W018161 |
| M.Wt: | 286.41 |
| Formula: | C16H30O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hexadecanedioic acid (Thapsic acid) is an orally active metabolite produced by B. uniformis. Hexadecanedioic acid inhibits IRE1α-XBP1s-mediated flipogenesis and ferroptosis. Hexadecanedioic acid downregulates XBP1 and Hrd1 expression, activates the Nrf2/SLC7A11/GPX4 pathway. Hexadecanedioic acid can be used for the research of metabolic-associated fatty liver disease[1]. In Vitro:Hexadecanedioic acid (40-80 μg/mL; 24 h) reduces hepatic steatosis and inhibits ferroptosis in free fatty acid-induced HepG2 cells by downregulating XBP1 and Hrd1, and upregulating the Nrf2/SLC7A11/GPX4 pathway[1]. In Vivo:Hexadecanedioic acid (8-16 mg/0.2 mL; I.g.,; every other day; 12 weeks) ameliorates high-fat diet-induced Metabolic Associated Fatty Liver Disease (MAFLD) in male C57BL/6J mice in a dose-dependent manner[1].
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