Suberic acid
CAS No. : 505-48-6
(Synonyms: Octanedioic acid)
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $29 | In-stock |
| 500g | $60 | In-stock |
| 1000g | $100 | In-stock |
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| Cat. No. : | HY-W015300 |
| M.Wt: | 174.20 |
| Formula: | C8H14O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness[1][2].
In Vitro:Suberic acid (100 μM) increases collagen production in UVB-irradiated Hs68 cells by activating the Akt signaling pathway[1].
Suberic acid (12.5-50 μM; 24 h) significantly reverses the decrease of procollagen I C-terminal peptide in a dose-dependent manner in UVB-irradiated Hs68 cells[2].
In Vivo:Suberic acid (0.05%-0.2% (w/w); p.o., dietary intake; 3 times per week; 10 weeks) can inhibit skin dryness, wrinkle formation and epidermal thickening, increase dermal collagen fiber density, and regulate the expression of molecules related to TGF-β and MAPK signaling pathways in a UVB-irradiated hairless mouse model[2].
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