TC-E 5008
CAS No. : 50405-58-8
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| Cat. No. : | HY-110144 |
| M.Wt: | 215.25 |
| Formula: | C13H13NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines[1][2].
In Vitro: TC-E 5008 (compound 2; 48 h) inhibits the production of D2HG with an EC50 value of 2.4 μM in HT1080 fibrosarcoma cells , which harbor an IDH1(R132C) mutation[1].
TC-E 5008 (2-10 μM; 72 h) has anti-proliferative activity on multiple ER positive breast cancer cell lines[2].
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- Cat. No.:
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