BRITE-338733

Cat. No. :	HY-112589
M.Wt:	433.59
Formula:	C27H35N3O2
Purity:	>98 %
Solubility:	DMSO : 10 mg/mL (ultrasonic;adjust pH to 4 with HCl);1 M HCl : 100 mg/mL (ultrasonic)

Introduction of 503105-88-2 :

BRITE-338733 is an inhibitor of E. coli RecA ATPase activity (IC₅₀: 4.7 μM). BRITE-338733 also inhibits the ATP hydrolysis activity of RSC chromatin remodeling enzyme by binding to its ATP-binding pocket and DNA (IC₅₀: 0.316 μM). BRITE-338733 exhibits cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells. BRITE-338733 can be used in studies on antibacterial adjuvants and anticancer research^[1][2].\n

IC50 & Target:IC50: 4.7 µM (RecA ATPase)^[1] In Vitro:BRITE-338733 exhibits strong and stable binding affinity for the ATPase domain of Sth1, the catalytic subunit of the yeast RSC complex^[2].
BRITE-338733 (0.5-1 mM; 20 min) potently inhibits the ATP hydrolysis activity of purified yeast RSC complex, with an IC₅₀ of 0.316 μM^[2].
BRITE-338733 (0.1-100 μM; 6-24 h) exhibits cytotoxicity against the human breast cancer cell lines MCF-7 and MDA-MB-231^[2].