Lonidamine
CAS No. : 50264-69-2
(Synonyms: AF-1890; Diclondazolic Acid; DICA)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $79 | In-stock |
| 25mg | $118 | In-stock |
| 50mg | $158 | In-stock |
| 100mg | $190 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-B0486 |
| M.Wt: | 321.16 |
| Formula: | C15H10Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis[1][2][3].
IC50 & Target: Ki: 2.5 μM (Mitochondrial pyruvate carrier)[2]
In Vitro: Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells[3].
Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation[4].
Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion[4].
Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities[4].
Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells[4].
In Vivo: Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model[3].
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