Sonolisib
CAS No. : 502632-66-8
(Synonyms: PX-866)
| Size | Price | Stock |
|---|---|---|
| 5mg | $360 | In-stock |
| 10mg | $576 | In-stock |
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| Cat. No. : | HY-N6775 |
| M.Wt: | 525.59 |
| Formula: | C29H35NO8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Sonolisib (PX-866), an improved Wortmannin analogue, is an oral, irreversible, and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)). Antitumor activity[1][2]. IC50 & Target: IC50: 0.1 nM (p110α), 1.0 nM (p120γ), 2.3 nM (p110δ)[2] In Vitro: Sonolisib (PX-866) inhibits the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations[3].
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