Hexahydrofarnesyl acetone

Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research^[1][2][3]. In Vitro:The essential oil of Lindera nacusua (containing 6.83% Hexahydrofarnesyl acetone, 0.2 mg of essential oil, 0.1 mL microbial suspension, 24 hours) exhibits significant antibacterial activity against Staphylococcus aureus and Candida albicans, with inhibition zones reaching 2.5 mm and 2.0 mm, respectively, surpassing the positive control, Amoxicillin (HY-B0467A)^[2].
The essential oil of Graptophyllum pictum (containing 2.6% Hexahydrofarnesyl acetone, 5 μL of essential oil, 3, 4, or 5 days) shows significant cytotoxicity against KB cells (epidermoid carcinoma of oral cavity), NCI-H187 cells (small cell lung carcinoma), and Vero cells (African green monkey kidney)^[2]。
In Vivo:The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) inhibits carrageenan (HY-125474)-induced inflammation in the paw edema model of Wistar rats^[1].
The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) exhibits analgesic effects in the formalin-induced pain model in Wistar rats^[1].