CTX1
CAS No. : 501935-96-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $270 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-U00442 |
| M.Wt: | 234.26 |
| Formula: | C14H10N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
CTX1 is a p53 activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system[1].
IC50 & Target: p53[1]
In Vitro: CTX1 binds directly to HdmX to prevent p53-HdmX complex formation, resulting in the rapidly induction of p53 in a DNA damage-independent manner[1].
In Vivo: CTX1 ( (30 mg/kg; i.p.; five days a week; for 3 weeks) significantly enhances the survival of mice in AML model system[1].
CTX1 exhibited significant anti-cancer activity alone as well as in combination with nutlin-3[1].
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