Org 43553
CAS No. : 501444-88-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $860 | In-stock |
| 10mg | $1380 | In-stock |
| 25mg | $2900 | In-stock |
| 50mg | $4650 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-19464 |
| M.Wt: | 514.66 |
| Formula: | C24H30N6O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine[1]. In Vitro: Org 43553 (0-3 μM; 4 h) shows agonistic activity to human LH, FSH and TSH receptors[1]. In Vivo: Org 43553 (5-50 mg/kg; p.o. once) triggers ovulation in immature mice and increases ovulation in GnRH-antagonist-treated rats[1]. Org 43553 (10-250 mg/kg; p.o. once) increases testosterone levels in male rats[1].
| Rats IV 5 mg/kg |
Rats PO 50 mg/kg |
Dogs IV 12.5 mg/kg |
Dogs PO 50 mg/kg |
|
| AUC (h mg/L) | 6.9±0.4 | 55.1±2.0 | 9.1±3.1 | 16.1±1.2 |
| Tmax (h) | 3.3±3.3 | 0.9±1.0 | ||
| Cmax (mg/L) | 5.1±2.3 | 3.8±0.9 | 8.7±2.2 | 4.1±1.7 |
| t1/2 (h) | 3.4±1.3 | 4.5±1.8 | 1.5±1.3 | 3.5±2.5 |
| CL (L/h) | 0.7±0.1 | 0.9±0.1 | 1.5±0.6 | 3.1±0.2 |
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