p-Coumaric acid

p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities^[1][2][3][4]. In Vitro:p-Coumaric acid (1 or 3 μg/mL, 24, 48, 72 h) can significantly inhibit the proliferation of human and mouse melanoma cells in vitro and promote cell apoptosis^[1].
p-Coumaric acid (10-80 μg/mL) shows antibacterial activity against both gram-negative and Gram-positive bacteria, and MIC values for Escherichia coli, Streptococcus dysenteriae and Salmonella typhimurium are 80, 10 and 20 μg/ml^[2].
In Vivo:p-Coumaric acid (50, 100, 200 mg/kg, suspended in 0.5% carboxymethyl cellulose (CMC), was administered daily via gastric cannula for 15 weeks) It has a protective effect on colon pretumor induced by 1,2 dimethylhydrazine (DMH) in rats^[3].
p-Coumaric acid (15, 100 mg/kg, oral) alleviates nephrotoxicity induced by Doxorubicin (HY-15142A) in rats by inhibiting oxidative stress, inflammation and apoptosis^[4].