Cardanol monoene

Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, cyclinA1 expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1 expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation^[1][2]. In Vitro:Cardanol monoene (2.5-40 μM; 24-48 h) inhibits human M14 melanoma cell proliferation with IC₅₀ values of 23.15 ± 2.42 μM at 24 h and 12.30 ± 1.67 μM at 48 h, acting in a dose-dependent and time-dependent manner^[1].
Cardanol monoene (10-50 μM; 2 weeks) dose-dependently reduces the colony-formation ability of human M14 melanoma cells, with 40 μM treatment lowering efficiency to 5.46% over 7 days^[1].
Cardanol monoene (10-40 μM; 48 h) dose-dependently inhibits human M14 melanoma cell migration over 48 h by down-regulating MMP-2 and MMP-9 protein expression^[1].
Cardanol monoene (10-40 μM; 24 h) induces dose-dependent S phase arrest in human M14 melanoma cells after 24 h treatment, reducing cyclinA1 mRNA expression and increasing CDK2 mRNA expression to inhibit cell proliferation^[1].
Cardanol monoene (10-50 μM; 24-48 h) induces dose-dependent caspase-mediated apoptosis in human M14 melanoma cells via up-regulating pro-apoptotic proteins (p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, Apaf-1), increasing the Bax/Bcl-2 ratio, and down-regulating anti-apoptotic Bcl-2, with 40 μM treatment causing 43.46% apoptotic cells after 24 h^[1].
Cardanol monoene (10-40 μM; 24 h) dose-dependently increases intracellular ROS levels in human M14 melanoma cells after 24 h treatment, with 40 μM causing a 65.27% increase relative to control^[1].
Cardanol monoene (10-40 μM; 24 h) dose-dependently induces mitochondrial depolarization in human M14 melanoma cells after 24 h treatment, with 40 μM reducing the red/green JC-1 fluorescence ratio to 50.37% of control^[1].
Cardanol monoene (40 μM; 24 h) alters the expression of 2527 genes in human M14 melanoma cells, with DEGs enriched in cancer-related pathways including Pathways in cancer, PI3K-Akt, MAPK, and p53 signaling pathways^[1].
Cardanol monoene shows weak DPPH radical scavenging and AChE inhibition activity^[2]. In Vivo:Cardanol monoene (1-1000 mg/mL; 24 h) is lethal to Artemia salina nauplii with an LC₅₀ of 43,186.00 ± 1991.00 μg/mL^[2].